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Treatment Approaches for Myeloproliferative Neoplasms  

Patient Case 1: Patient with Intermediate Risk Myelofibrosis

Videos

Expert perspectives on the management of myeloproliferative neoplasms (MPNs) from a virtual tumor board discussion. The segments cover treatment approaches, including the use of JAK inhibitors, and key efficacy and safety data from clinical trials that inform treatment selection.

This segment discusses the current classification of myeloproliferative neoplasms (MPNs) and the pathogenesis of these disorders, particularly the role of the JAK-STAT signaling pathway. It also presents a treatment algorithm for higher-risk myelofibrosis, with a focus on the use of JAK inhibitors such as ruxolitinib, fedratinib, pacritinib, and momelotinib.

Treatment Approaches for Myeloproliferative Neoplasms

Medical experts discuss a patient case highlighting a 68-year old woman who is uninterested in transplantation and treatment with ruxolitinib has been initiated.

Expert panelists highlight the COMFORT I and COMFORT II studies.

Review of COMFORT I and COMFORT II Trials

Key findings from COMFORT I and COMFORT II studies are examined.

Expert Takeaways from COMFORT I and II Trial Results

Medical experts discuss strategies to navigate a complex patient scenario pertaining to previous refusal of ASCT.

Managing Treatment Strategy for Patient Who Previously Declined ASCT

Prithviraj Bose, MD, introduces study designs for trials focusing on JAK inhibitor utilization in patients receiving treatment for myelofibrosis.

Key Clinical Trials Highlighting JAK Inhibitors in Myelofibrosis Treatment

The panel of experts dissect findings around breaking JAK inhibitor data in myelofibrosis treatment.

Reviewing Impact of Emerging JAK Inhibitor Data

Dr Bose drives a discussion surrounding the treatment of advanced polycythemia vera.

Treatment of Advanced Polycythemia Vera

Downstream impacts of ruxolitinib in polycythemia vera treatment are illustrated by a panel of medical experts.

Long-Term Outcomes with Ruxolitinib in Polycythemia Vera

This segment discusses the key efficacy and safety considerations from the PROUD-PV and CONTINUATION-PV trials evaluating ropeginterferon alfa-2b as a treatment option for polycythemia vera.

PROUD-PV/CONTINUATION-PV Trials for Ropeginterferon Alfa-2b in Polycythemia Vera

With their final discussion the panel examines the survival outcomes and risk of thromboembolic/hemorrhagic events from the MAJIC-PV trial, which compared ruxolitinib to best available therapy in polycythemia vera patients resistant or intolerant to hydroxyurea.

MAJIC-PV Trial: Ruxolitinib vs Best Available Therapy in Hydroxyurea-Resistant/Intolerant Polycythemia Vera

Expert Perspective Tumor Board

Review of COMFORT I and COMFORT II Trials

EP: 1.Treatment Approaches for Myeloproliferative Neoplasms

EP: 2.Patient Case 1: Patient with Intermediate Risk Myelofibrosis

EP: 3.Review of COMFORT I and COMFORT II Trials

EP: 4.Expert Takeaways from COMFORT I and II Trial Results

EP: 5.Managing Treatment Strategy for Patient Who Previously Declined ASCT

EP: 6.Key Clinical Trials Highlighting JAK Inhibitors in Myelofibrosis Treatment

EP: 7.Reviewing Impact of Emerging JAK Inhibitor Data

EP: 8.Treatment of Advanced Polycythemia Vera

EP: 9.Long-Term Outcomes with Ruxolitinib in Polycythemia Vera

EP: 10.PROUD-PV/CONTINUATION-PV Trials for Ropeginterferon Alfa-2b in Polycythemia Vera

EP: 11.MAJIC-PV Trial: Ruxolitinib vs Best Available Therapy in Hydroxyurea-Resistant/Intolerant Polycythemia Vera