Raghav Discusses the Choice of Regorafenib or TAS-102 in Metastatic CRC

Kanwal Raghav, MBBS, MD, associate professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses factors that should be considered when deciding on treatment for a patient with metastatic colorectal cancer (mCRC).

Regorafenib (Stivarga) and TAS-102 are both targeted therapies used for the treatment of mCRC. Raghav explains that no rationale exists for the use of one therapy over the other because the clinical trial research supporting these agents was performed in the same patient population. However, there are some differences in how the agents are utilized, says Raghav. For example, oncologists tend to administer regorafenib before TAS-102.

There are other clinical trials for both regorafenib and TAS-102 to determine the activity of the agents in combination with other drugs. Research has already demonstrated the TAS-102 has efficacy in patients who have developed resistance to regorafenib and that regorafenib can be a bridge o TAS-102 therapy. It has also been shown that these agents have different toxicity profiles, and for TAS-102, some may be dose-limiting.