monarchE Investigators Set Out to Make Practice-Changing Impact in Breast Cancer
Nadia Harbeck, MD, PhD, discusses how the monarchE trial, which evaluated the efficacy of endocrine therapy with or without abemaciclib, will change breast cancer treatment.
Nadia Harbeck, MD, PhD, the head of the Breast Center at the European Society of Medial Oncology and the chair of the Conservative Oncology Department at the University of Munich, discusses how the monarchE trial, which evaluated the efficacy of endocrine therapy with or without abemaciclib (Verzenio), will change breast cancer treatment.
According to Harbeck, the monarchE trial is the first study to look at centralized prospective Ki-67 measures with a cut off at 20%. The study accomplished 2 things. First, it validated Ki-67 as a prognostic biomarker, even in clinically high-risk patients. Secondly, it showed the benefit of abemaciclib versus endocrine therapy alone in both Ki-67-high and Ki-67-low tumors, showing that the benefit of the agent was independent of levels.
Additionally, monarchE found that in clinically high-risk Ki-67-low tumors, better outcomes were seen in both arms. According to Harbeck, the findings warrants further follow-up investigation.
Therapy Type and Site of Metastases Factor into HR+, HER2+ mBC Treatment
December 20th 2024During a Case-Based Roundtable® event, Ian Krop, MD, and participants discussed considerations affecting first- and second-line treatment of metastatic HER2-positive breast cancer in the first article of a 2-part series.
Read More
Imlunestrant Improves PFS in ESR1-Mutant Advanced Breast Cancer
December 13th 2024The phase 3 EMBER-3 trial showed imlunestrant improved PFS over SOC endocrine therapy in ER-positive, HER2-negative advanced breast cancer with ESR1 mutations, though not significantly in the overall population.
Read More
Breast Cancer Leans into the Decade of Antibody-Drug Conjugates, Experts Discuss
September 25th 2020In season 1, episode 3 of Targeted Talks, the importance of precision medicine in breast cancer, and how that vitally differs in community oncology compared with academic settings, is the topic of discussion.
Listen
Postoperative Radiation Improves HRQOL Over Endocrine Therapy in Breast Cancer
December 13th 2024In the phase 3 EUROPA trial, exclusive postoperative radiation therapy led to better health-related quality of life and fewer treatment-related adverse events in older patients with stage I luminal-like breast cancer at 24 months.
Read More
