Management of BsAb Toxicities by Community Oncologists Across Therapeutic Indications

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Dr Graff discusses the differences and similarities in managing adverse events associated with bispecific antibodies in non-Hodgkin lymphoma compared to other therapeutic indications, such as multiple myeloma and non–small cell lung cancer.

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Review the recommendations on identifying, evaluating, and managing neurological toxicities.

  • Workup and evaluation
  • Grading of neurological toxicity
  • Management of neurological toxicities
  • Are there any other toxicities that are important to mention?

Please discuss the differences/similarities of bispecific antibody (BsAb) adverse event management in non-Hodgkin lymphoma vs other therapeutic indications (eg, multiple myeloma, non–small cell lung cancer).

  • Is there a greater incidence of cytokine release syndrome or neurological toxicity in one disease state vs the other?
  • Please address differences in BsAb protocols in different disease states.
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