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Opinion|Videos|November 4, 2024

Management of BsAb Toxicities by Community Oncologists Across Therapeutic Indications

Author(s)Jennifer Crombie, MD , Matthew J. Matasar, MD, Tara Graff, DO

Dr Graff discusses the differences and similarities in managing adverse events associated with bispecific antibodies in non-Hodgkin lymphoma compared to other therapeutic indications, such as multiple myeloma and non–small cell lung cancer.

Episodes in this series

EP. 1 Intro and Overview of Bispecifics in Non-Hodgkin Lymphoma (NHL)

EP. 1 Intro and Overview of Bispecifics in Non-Hodgkin Lymphoma (NHL)

EP. 2 CD3×CD20 Bispecific Toxicities and Consensus Recommendations for Managing

EP. 2 CD3×CD20 Bispecific Toxicities and Consensus Recommendations for Managing

EP. 3 Community Oncologist Perspective: CD3×CD20 Bispecific Toxicities and Consensus Recommendations

EP. 3 Community Oncologist Perspective: CD3×CD20 Bispecific Toxicities and Consensus Recommendations

EP. 4 Protocol Development for Administration and AE Management of Bispecifics

EP. 4 Protocol Development for Administration and AE Management of Bispecifics

EP. 5 Community Oncologist Perspective: Protocol Development for Bispecific Administration and AE Management

EP. 5 Community Oncologist Perspective: Protocol Development for Bispecific Administration and AE Management

EP. 6 Exploring the Management of Cytokine Release Syndrome (CRS)

EP. 6 Exploring the Management of Cytokine Release Syndrome (CRS)

EP. 7 Academic Perspectives for Evaluating, Identifying, and Managing CRS

EP. 7 Academic Perspectives for Evaluating, Identifying, and Managing CRS

EP. 8 Community Oncologist Perspective: Evaluating, Identifying, and Managing CRS

EP. 8 Community Oncologist Perspective: Evaluating, Identifying, and Managing CRS

EP. 9 Clinical Recommendations for Neurological Toxicities

EP. 9 Clinical Recommendations for Neurological Toxicities

EP. 10 Community Oncologist Perspective: Clinical Recommendations for Neurological Toxicities

EP. 10 Community Oncologist Perspective: Clinical Recommendations for Neurological Toxicities

EP. 11 Management of BsAb Toxicities by Community Oncologists Across Therapeutic Indications

EP. 11 Management of BsAb Toxicities by Community Oncologists Across Therapeutic Indications

EP. 12 Community Oncologist Perspective: Initiation, Hospitalization, and Monitoring of Bispecifics

EP. 12 Community Oncologist Perspective: Initiation, Hospitalization, and Monitoring of Bispecifics

EP. 13 Patient Referrals of Bispecifics and Collaborative Efforts with Community Centers

EP. 13 Patient Referrals of Bispecifics and Collaborative Efforts with Community Centers

EP. 14 Perceptions on the Future of Bispecific Therapies for NHL

EP. 14 Perceptions on the Future of Bispecific Therapies for NHL

EP. 15 Community Oncologist Perspective: Future of Bispecific Therapies for NHL

EP. 15 Community Oncologist Perspective: Future of Bispecific Therapies for NHL

Video content above is prompted by the following:

Review the recommendations on identifying, evaluating, and managing neurological toxicities.

Workup and evaluation
Grading of neurological toxicity
Management of neurological toxicities
Are there any other toxicities that are important to mention?

Please discuss the differences/similarities of bispecific antibody (BsAb) adverse event management in non-Hodgkin lymphoma vs other therapeutic indications (eg, multiple myeloma, non–small cell lung cancer).

Is there a greater incidence of cytokine release syndrome or neurological toxicity in one disease state vs the other?
Please address differences in BsAb protocols in different disease states.

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