Ivosidenib Produces Encouraging OS Data in Previously Treated Cholangiocarcinoma
Andrew X. Zhu, MD, PhD, discusses the final results from the phase 3 ClarIDHy study of ivosidenib versus placebo as treatment of patients with previously treated cholangiocarcinoma and an IDH1 mutation.
Andrew X. Zhu, MD, PhD, professor of medicine at the Harvard Medical School and director of Liver Cancer Research at the Massachusetts General Hospital Cancer Center, discusses the final results from the phase 3 ClarIDHy study of ivosidenib (Tibsovo) versus placebo as treatment of patients with previously treated cholangiocarcinoma and an IDH1 mutation.
Overall, the findings demonstrated a numeric improvement in overall survival (OS) with ivosidenib compared with placebo. In the intent-to-treat population, the median OS was 10.3 months with ivosidenib versus 7.5 months with placebo. Interestingly, Zhu says 70% of patients in the placebo arm crossed over, but despite the high crossover rate, there was still a trend for median OS improvement.
In a respecified analysis, the adjusted median OS still demonstrated significant improvement with ivosidenib, says Zhu. In addition, when looking at the safety of this therapy in patients with cholangiocarcinoma, the agent had a very favorable safety profile. According to Zhu, these findings are encouraging.
Ilson Examines Chemoimmunotherapy Regimens for Metastatic Gastroesophageal Cancers
December 20th 2024During a Case-Based Roundtable® event, David H. Ilson, MD, PhD, discussed the outcomes of the CheckMate 649, CheckMate 648, and KEYNOTE-859 trials of chemoimmunotherapy regimens in patients with upper GI cancers.
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AI-Driven Deep Learning Model Shows Promise in Standardizing MDS Diagnosis
December 10th 2024In an interview, Palak Dave discussed how artificial intelligence, using deep learning to analyze bone marrow aspirate smear images, could standardize and accelerate the diagnosis of MDS vs pre-MDS conditions.
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