Exploring Innovations in Lymphoma Treatment With Russler-Germain

David A. Russler-Germain, MD, PhD, physician-scientist at Washington University School of Medicine and Siteman Cancer Center, discusses his path in oncology and the many advancements shaping lymphoma treatment today.

In this episode, he shares how his early exposure to academic medicine inspired his decision to pursue an MD-PhD, leading him to a career in lymphoma research. He reflects on the major treatment shifts he has witnessed, from traditional chemotherapy to the rise of targeted therapies, Bruton’s tyrosine kinase inhibitors, chimeric antigen receptor T-cell therapy, and bispecific antibodies. He explains how these developments have transformed patient outcomes and continue to drive progress in the field.

One main focus of the discussion is Germain’s research on the genomic profiling of follicular lymphoma, where he has identified critical mutations and their clinical implications. Another topic discussed is circulating tumor DNA (ctDNA) and its emerging role in the management of patients with lymphoma.

Germain explains how ctDNA can serve as a non-invasive biomarker and enable real-time monitoring of disease response and relapse. However, he also highlights the challenges of integrating advanced genomic testing and precision medicine into community oncology practices, where access to cutting-edge diagnostics and therapies may be limited.

Beyond research, Germain concludes the conversation by providing helpful insights into the biggest challenges in lymphoma care today. He shares his perspective on the most promising areas of innovation in oncology and offers advice for other emerging experts looking to make an impact in this rapidly evolving field.

“I would encourage everyone, especially junior investigators like myself, to be active participants in multiple realms of research,” Germain says. “So, staying aware of the literature, calling a friend if you need help, putting in that little extra effort to sort of solve those mysteries would be important for patient care, in my opinion.”