|Videos|July 16, 2018

The Clinical Management of Primary Myelofibrosis

March 2017

A 67-year old woman presents to her primary care physician with complaints of fatigue, abdominal fullness, night sweats, and 17-lb weight loss over the past 6 months.
PMH includes hypertension, controlled on enalapril 10 mg
Abdominal examination reveals spleen palpable 7 cm below the costal margin
Lab values:
- HGB: 9.2 gm/dl
- Platelets: 189 x 10⁹/L
- WBC: 19 x 10⁹/L
Bone Marrow Biopsy:
- MF-3
- CD34+/CD117+ immunostaining demonstrated 1.2% blasts
- JAK-V617F mutation
Diagnosis: Primary myelofibrosis

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