Alexander Spira, MD, PhD, FACP, discusses the prognosis of patients with EGFR- exon 20 mutated non-small cell lung cancer.
Alexander Spira, MD, PhD, FACP, director of the Virginia Cancer Specialists, discusses the prognosis of patients with EGFR- exon 20 mutated non-small cell lung cancer (NSCLC).
According to Spira, the prognosis is not as good as other EGFR mutations as there are no targeted therapies. The prognosis of this patient population is similar to that with EGFR wild type.
EGFR-exon 20 mutated NSCLC is treated just like any other lung cancer currently. It is an actionable mutation, and more therapies are needed in order to target it.
0:08 | The prognosis is clearly not as good as other EGFR mutations because there are no targeted therapies. So, it's clearly worse prognosis with an average length of diagnosis, probably similar to wild type patients without the new treatments that are coming.
0:25 | The challenge is before we get some drugs that we are hopefully going to have approved soon, is that it is just treated like other lung cancers. So, we know there's a targeted mutation. And it's been very frustrating because you have a targeted mutation, but you couldn't act on it. So, the hope is that, obviously with some new treatments, we'll be able to change that significantly because were being teased for our patients that we know there's something there, but you can't do
FDA Clears Lazertinib/Amivantamab for First-Line EGFR-Mutated NSCLC
August 20th 2024Lazertinib and amivantamab as a first-line treatment for patients with locally advanced or metastatic non–small cell lung cancer with specific EGFR mutations demonstrated superior efficacy compared with standard treatment.
Read More
Osimertinib Offers New Standard of Care in Stage III EGFR-Mutated NSCLC
August 6th 2024Suresh S. Ramalingam, MD, discussed the practice-changing findings and implications of the phase 3 LAURA study investigating osimertinib for the treatment of patients with EGFR-mutated non–small cell lung cancer.
Read More