Dr. Sylvia Asa on Thyroid Cancer Genotyping
Dr. Sylvia Asa, MD, PhD, pathologist with the Toronto General Hospital/Research Institute (UHN) and a professor at the University of Toronto, discusses genotyping and the role it can play in diagnosing and selecting targeted treatments for thyroid cancer.
Dr. Sylvia Asa, MD, PhD, pathologist with the Toronto General Hospital/Research Institute (UHN) and a professor at the University of Toronto, discusses genotyping and the role it can play in diagnosing and selecting targeted treatments for thyroid cancer.
Targeted therapies based on genetic mutations are a more recent phenomenon in thyroid cancers, but pathologists have recognized phenotypes of thyroid cancer for more than 50 years that are based on genotypic findings but that don’t require the genotype to make a diagnosis, prognosis, or to determine predictive therapy, says Asa.
BRAF has emerged as the most common genetic mutation in thyroid cancer. However, unlike in most other BRAF-mutated cancers, BRAF-mutated thyroid cancers do not seem to respond well to targeted therapies. Understanding epigenetic changes may play an important role in better treating thyroid cancer, says Asa.
Anticipating Novel Options for the RAI-Refractory DTC Armamentarium
May 15th 2023In season 4, episode 6 of Targeted Talks, Warren Swegal, MD, takes a multidisciplinary look at the RAI-refractory differentiated thyroid cancer treatment landscape, including the research behind 2 promising systemic therapy options.
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