Case: A 65-Year-Old Woman withIDH2-Mutated AML
November 2017
- A 65-year-old female was diagnosed with AML, normal cytogenetics;IDH2R140,RUNX1,andDNMT3Amutations
- 7+3 induction chemotherapy was initiated
- Her treatment course was complicated by mucositis and febrile neutropenia
- After resolution of her complications, she received 2 cycles of intermediate-dose cytarabine consolidation
May 2018
- Now, 6 months after her initial diagnosis, she presents with fatigue, aches, and gum bleeding
- Labs: leukocytosis, 20% circulating myeloblasts, ANC 450 cells/mL
- Bone marrow biopsy: hypercellular 80% blast, normal cytogenetics
- NGS: mutations inIDH2,RUNX1,andDNMT3A