Combining HDAC Inhibitors With Immunotherapy in Melanoma
Sanjiv S. Agarwala, MD, chairman of medical oncology at St. Luke’s University Health Network, discusses the combination of immunotherapy and a histone deacetylase inhibitor in patients with melanoma, as well as other types of cancer.
Sanjiv S. Agarwala, MD, chairman of medical oncology at St. Luke’s University Health Network, discusses the combination of immunotherapy and a histone deacetylase (HDAC) inhibitor in patients with melanoma, as well as other types of cancer.
Agarwala says that HDAC/immunotherapy combinations, such as seen with pembrolizumab (Keytruda) plus entinostat, could have promise in other diseases in addition to melanoma. Entinostat could also be combined with nivolumab (Opdivo) or other PD-1/PD-L1 antibodies, Agarwala says.
Enasidenib Shows Promise as Post-Transplant Maintenance in IDH2-Mutated AML
January 7th 2025Amandeep Salhotra, MD, discussed the background and findings from a pilot trial evaluating enasidenib as post-hematopoietic stem cell transplant maintenance therapy for IDH2-mutated acute myeloid leukemia treatment.
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