Combining Azacitidine/Enasidenib to Enhance the Treatment of Newly Diagnosed IDH2-Mutant AML
Courtney D. DiNardo, MD, MSCE, explains the rationale for the phase II AG221-AML-005 trial.
Courtney D. DiNardo, MD, MSCE, an assistant professor in the Department of Leukemia, Division of Cancer Medicine at the University of Texas MD Anderson Cancer Center, explains the rationale for the phase II AG221-AML-005 trial.
For the older population of patients with acute myeloid leukemia (AML), the current standard of care in the United States is azacitidine (Vidaza). The drug can lead to a complete remission rate of about 20%, an overall response rate of about 30%, and overall survival of around 12 months, says DiNardo.
The IDH2 inhibitor enasidenib (Idhifa) has been approved for the treatment of relapsed/refractoryIDH2-mutated AML, and it’s promising activity in this patient population raised the question of whether patients who were newly diagnosed withIDH2-mutant AML could derive benefit from enasidenib in combination with azacitidine.
For more on the AG221-AML-005 trial:https://www.targetedonc.com/news/enasidenib-plus-azacitidine-expands-treatment-landscape-for-idh2mutant-aml
Advancing Neoadjuvant Therapy for HER2+ Breast Cancer Through ctDNA Monitoring
December 19th 2024In an interview with Targeted Oncology, Adrienne Waks, MD, provided insights into the significance of the findings from the DAPHNe trial and their clinical implications for patients with HER2-positive breast cancer.
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