Apalutamide Combination is Well Tolerated in Metastatic Castration-Sensitive Prostate Cancer
Kim N. Chi, MD, discusses the safety findings for the next-generation androgen receptor inhibitor apalutamide in combination with androgen deprivation therapy in patients with metastatic castration-sensitive prostate cancer, according to findings from the phase III TITAN study. This combination was compared with placebo and ADT and presented at the 2019 ASCO Annual Meeting.
Kim N. Chi, MD, a professor at the University of British Columbia and a medical oncologist at BC Cancer Vancouver, discusses the safety findings for the next-generation androgen receptor (AR) inhibitor apalutamide (Erleada) in combination with androgen deprivation therapy (ADT) in patients with metastatic castration-sensitive prostate cancer, according to findings from the phase III TITAN study. This combination was compared with placebo and ADT and presented at the 2019 ASCO Annual Meeting.
Overall, apalutamide plus ADT was well tolerated in this patient population. The safety profile was not that different from the placebo arm in this trial, says Chi. However, there are some specific adverse events to be noted, including rash and hypothyroidism.
Rash occurred in 27% of the patients in this trial, and it was typically grade 1 or 2. This mild rash can be managed symptomatically or with creams, says Chi. Two percent of patients in the TITAN trial discontinued treatment due to rash.
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