42-Month Follow-Up Data of Acalabrutinib Monotherapy in R/R CLL
December 10th 2019<br /> Richard R. Furman, MD, professor of medicine, Morton Coleman, MD Distinguished Professor of Medicine, director, Chronic Lymphocytic Leukemia Research Center, Weill Cornell Medicine, and attending physician, NewYork-Presbyterian Hospital, discusses the 42-month follow-up data of acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia.
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Bendamustine/Rituximab as Induction Therapy in MCL
December 9th 2019<br /> Diego Villa, MD, MPH, clinical associate professor, Division of Medical Oncology, The University of British Columbia, discusses a retrospective analysis evaluating bendamustine and rituximab as induction therapy in both transplant eligible and ineligible patients with mantle cell lymphoma. <br />
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Identification of EGFR Mutations Impacts Overall Prognosis in Lung Cancers
December 7th 2019Brennan J. Decker, MD, PhD, discusses the role of identifying <em>EGFR</em> mutations in patients with lung cancers. In lung adenocarcinoma, there are many different activating mutations that can lead to the development of cancer, Decker explains.
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Expert Discusses Evolving Role of Genetic Testing in Prostate Cancer
December 6th 2019James L. Mohler, MD, discusses the evolving role of genetic testing in patients with prostate cancer following the updates to the National Cancer Care Network Guidelines, which now include guidance for better practice in terms of conducting genetic testing in this patient population.
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Phase II Evaluates Vemurafenib/Obinutuzumab in Hairy Cell Leukemia
December 6th 2019Justin Taylor, MD, discusses the rationale for an ongoing phase II trial that is exploring the combination of vemurafenib, a BRAF inhibitor, plus the anti-CD20 monoclonal antibody obinutuzumab in previously untreated patients with classical hairy cell leukemia.
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Survival Benefit Confirmed in Real-Life Analysis of Second-Line Regorafenib in HCC
December 6th 2019María Varela, MD, PhD, discusses the findings from a real-life analysis to confirm the benefit of regorafenib as treatment of patients with hepatocellular carcinoma who have progressed on prior sorafenib. Regorafenib was approved by the FDA for second-line treatment in this patient population based on data from the phase III RESORCE trial.
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Adjuvant Chemotherapy Benefit Observed in Patients With Advanced Bladder Cancer
December 5th 2019Brain C. Baumann, MD, assistant professor of radiation oncology, Department of Radiation Oncology, Washington University School of Medicine St. Louis, explains the rationale for the study of adjuvant chemotherapy plus radiation versus radiation alone in patients with locally advanced bladder cancer.
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Rationalizing the Use of Pembrolizumab/Bevacizumab in Women With Recurrent Ovarian Cancer
December 4th 2019Emese Zsiros, MD, PhD, FACOG, assistant professor of oncology, Department of Gynecologic Oncology, Center for Immunotherapy, Roswell Park Comprehensive Cancer Center explains the rationale for the a phase II study, which combined pembrolizumab with bevacizumab in patients with recurrent ovarian cancer. Zsiros presented data on the study in early 2019 at the SGO Annual Meeting.
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Enhancing Benefit With Durvalumab in NSCLC After the PACIFIC Trial
December 3rd 2019Andreas Rimner, MD, gives an overview of his presentation titled, “Crossing the PACIFIC,” which he presented at the 2019 New York Lung Cancers Symposium. He evaluates some potential next steps for durvalumab (Imfinzi) following the practice-changing results from the PACIFIC trial.
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Brentuximab Vedotin Adds Benefit to A+AVD Therapy in cHL
December 3rd 2019Andrew M. Evens, DO, MSc, discusses the significance of the results from the phase III ECHELON-1 trial in which patients with stage III/IV classical Hodgkin lymphoma were treated with the combination of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine.
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Immunotherapy Versus Targeted Therapy for Advanced Melanoma
December 3rd 2019Adil Daud, MD, compares the roles of immunotherapy versus dabrafenib plus trametinib targeted therapy combinations in patients with advanced melanoma. The latter combination is appropriate and even preventative in select patients, but the decision between checkpoint immune therapy and immunotherapy comes down to what is best for each patient.
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Continuing the Overall Survival Analysis in the MONARCH-2 Trial
December 3rd 2019George W. Sledge, Jr., MD, professor of medicine, Stanford University Medical Center, discusses the next steps for the phase III MONARH-2 trail following the positive interim analysis results presented during the 2019 European Society of Medical Oncology Congress.
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