Avelumab Plus Best Supportive Care Shows Efficacy in Urothelial Carcinoma
June 24th 2020Petros Grivas, MD, PhD, discusses the JAVELIN Bladder 100 trial of maintenance avelumab plus best supportive care versus best supportive care alone after platinum-based first-line chemotherapy in patients with advanced urothelial carcinoma.
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Mirvetuximab Soravtansine Combination Improves Responses in Platinum-Agnostic Ovarian Cancer
June 24th 2020Lucy Gilbert, MD, MSc, discusses the findings from a phase 1b trial in which mirvetuximab soravtansine was combined with bevacizumab in recurrent, high-grade epithelial ovarian cancer regardless of platinum sensitivity.
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Dabrafenib Plus Trametinib Demonstrates Benefit in BRAF-Mutant Melanoma
June 23rd 2020Axel Hauschild, MD, PhD, discusses the key findings from the phase 3 COMBI-AD clinical trial, which demonstrated sustained long-term relapse-free survival benefit with the combination of dabrafenib and trametinib compared with placebo in patients with resected, stage III BRAF V600E/K-mutated melanoma.
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Azacitadine Plus Pevonedistat Shows Efficacy in MDS/CMML or LB AML
June 23rd 2020Mikkael Sekeres, MD, discusses a phase 2 study of pevonedistat plus azacitidine versus azacitadine monotherapy in patients with higher-risk myelodysplastic syndromes /chronic myelomonocytic leukemia or low-blast acute myelogenous leukemia.
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