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The MDM2 antagonist idasanutlin was found to be clinically active and well tolerated in patients with previously treated polycythemia vera. Additionally, on-target <em>TP53 </em>pathway activation was observed in treatment-refractory patients with PV who were treated with idasanutlin, according to the results of a phase I clinical trial.<br /> &nbsp;

During an interview with <em>Targeted Oncology</em>, Guru P. Sonpavde, MD highlights the extensive research around checkpoint inhibition and chemotherapy combinations and how these regimens are advancing bladder cancer treatment.

Anna C. Pavlick, DO, MS, MBA, spoke with a group of physicians about the systemic therapy options, including immunotherapeutics, for treating patients with cutaneous carcinomas in a recent&nbsp;<em>Targeted Oncology&nbsp;</em>live case-based peer perspectives discussion. Pavlick explained treatment options based on 2 case scenarios of patients with cutaneous malignancies.

PF-05280586, a biosimilar for rituximab, has been approved by the FDA for use as a single-agent or in combination with chemotherapy for the treatment of&nbsp;adult patients with CD20-positive B-cell non-Hodgkin lymphoma, or in combination with chemotherapy for patients with CD20-positive chronic lymphocytic leukemia.

The FDA has granted a breakthrough therapy designation for the combination of pembrolizumab and lenvatinib for the treatment of patients with newly diagnosed, advanced, unresectable hepatocellular carcinoma that is not amenable to locoregional treatment.

The results of the phase III PACIFIC trial made a significant impact on the treat&shy;ment landscape for locally advanced non&minus;small cell lung cancer when both the progression-free survival and overall survival results were announced separately.

Over the past 2 years, the amount of FDA-approved frontline treatments for patients with acute myeloid leukemia have increased. These emergent treatments have caused a shift in the standard of care for patients with AML and inspiring analyses of regimens that researchers believe can improve outcomes for AML treatment.&nbsp;

Neratinib has received approval from Health Canada for the treatment of patients with early-stage, hormone receptor&ndash;positive, HER2-overexpressed/amplified breast cancer in the extended adjuvant setting. The agent should be given to patients 1 year after completing trastuzumab-based adjuvant therapy.<br /> &nbsp;

In an interview with&nbsp;<em>Targeted Oncology</em>, David Polsky, MD, PhD, discussed the findings from this analysis in patients with&nbsp;<em>BRAF</em>-mutant, unresectable, metastatic melanoma. He highlighted the next steps necessary for validating these findings and potentially using ctDNA to help inform treatment decisions for patients with metastatic melanoma.

The FDA has approved an update to the durvalumab label for patients with unresectable, stage III non&ndash;small cell lung cancer whose disease has not progressed following concurrent platinum-based chemoradiotherapy in order to include overall survival data from the phase III PACIFIC trial.<br /> &nbsp;

In an interview with&nbsp;Targeted Oncology, Richard S. Finn, MD, discussed the findings from the KEYNOTE-240 trial. He says that although these results were not statistically significant, they are still clinically meaningful.

A phase III trial is being initiated to evaluate the combination of regorafenib and nivolumab in comparison with regorafenib alone in patients with microsatellite stable metastatic colorectal cancer.

Novel agent namodenoson demonstrated tolerability in a favorable safety profile in patients with advanced hepatocellular carcinoma and severe liver dysfunction, according to the results of a randomized phase II trial.

In an interview with&nbsp;Targeted Oncology, Mark J. Levis, MD, PhD, discussed the findings from the follow-up analyses of the ADMIRAL trial that were presented at the 2019 ASCO Annual Meeting. He explained what these findings mean for the patient and what questions future research will aim to answer.

Treatment with 3D conformal radiotherapy prior to hepatectomy significantly improved post-operative outcomes compared with surgery alone in patients with resectable hepatocellular carcinoma and portal vein tumor thrombus, according to the results of randomized study published in the&nbsp;<em>Journal of Clinical Oncology</em>.<br /> &nbsp;

A combined regimen of pazopanib and trametinib was tolerable at full single-agent doses in patients with differentiated thyroid cancer according to the results of a multicenter phase I trial expansion cohort. The expansion cohort showed that the combination has clinical activity in DTC but did not achieve the pre-specified response rate, according to a new report in&nbsp;<em>Clinical Cancer Research</em>.

Testosterone suppression with docetaxel, the standard of care for patients with metastatic hormone-sensitive prostate cancer (mHSPC), was combined with chemotherapy or enzalutamide (Xtandi) to assess the potential improvement in overall survival compared with non-steroidal anti-androgens like bicalutamide, nilutamide, and flutamide in the&nbsp;phase III ENZAMET trial.&nbsp;<br /> &nbsp;

Jane Lowe Meisel, MD, reviewed systemic therapy options for treating patients with breast cancer with a group of physicians during a&nbsp;<em>Targeted Oncology&nbsp;</em>live case-based peer perspectives discussion. Meisel explained the treatment considerations she makes for treating patients with breast cancer during the dinner event in terms of 2 case studies.

A dose-escalation strategy for giving regorafenib improved the frequency of adverse events while still demonstrating similar efficacy to a standard-dose strategy in patients with metastatic colorectal cancer.

The combination of erlotinib and ramucirumab showed better progression-free survival in patients with newly diagnosed&nbsp;<em>EGFR</em>-mutant metastatic non&ndash;small cell lung cancer compared with erlotinib plus placebo, based on findings from the RELAY trial presented during the 2019 ASCO Annual Meeting.&nbsp;

Biologics License Application for enfortumab vedotin has been submitted to the FDA for a potential accelerated approval for use as a treatment for patients with locally advanced or metastatic urothelial cancer who have previously received a PD-1/PD-L1 inhibitor and platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced, or metastatic setting.

A single-arm, multicenter phase II trial held in China analyzed the Bruton&rsquo;s tyrosine kinase inhibitor zanubrutinib for treatment of patients with relapsed/refractory mantle cell lymphoma. Previously, the investigational BTK inhibitor gained a&nbsp;breakthrough&nbsp;designation&nbsp;from the&nbsp;FDA&nbsp;based on early results from the phase II trial that showed zanubrutinib to be highly active.<br /> &nbsp;

In an interview with&nbsp;Targeted Oncology, James Chih-Hsin Yang, MD discussed the updated findings from the FLAURA trial, which confirmed durable responses with frontline osimertinib in patients with&nbsp;EGFR-positive NSCLC. He highlighted what areas research will be focusing on in the coming years for patients harboring&nbsp;EGFR&nbsp;mutations.

The latest results from the CheckMate 032 trial have found that the combination of nivolumab plushigher-dose ipilimumab improved the objective response rate in heavily pretreated patients with metastatic urothelial carcinoma compared with nivolumab monotherapy or a combined regimen with a lower dose ofipilimumab.

In the phase III PRIMA trial, niraparib demonstrated a benefit in progression-free survival compared with placebo when used as maintenance therapy following platinum-based chemotherapy for patients with ovarian cancer treated in the first line.&nbsp;The PFS benefit was found to be statistically significant, regardless of patients&rsquo; biomarker status, meeting the primary endpoint of the trial.&nbsp;

In an interview with&nbsp;<em>Targeted Oncology</em>, Susan Branford, PhD discussed the current role of NGS testing in hematologic malignancies. Following her presentation at the 2019 EHA Congress, she addressed how NGS can be incorporated more into the community practice and what challenges must be overcome in order to make this happen.

A Biologics License Application was submitted to the FDA seeking approval for a new subcutaneous formulation of daratumumab in select patients with multiple myeloma.

The investigational agent SM-88 demonstrated promising survival in the phase II TYME-88-Panc study in patients with advanced pancreatic cancer.^1,2&nbsp;The&nbsp;oral modified dysfunctional tyrosine induced a median overall survival of 6.4 months in patients.<br /> &nbsp;

The FDA has granted an orphan drug designation to durvalumab (Imfinzi) for the treatment of patients with small cell lung cancer (SCLC).<br /> &nbsp;

Catherine Frenette, MD, explained in a&nbsp;Targeted Oncology&nbsp;live case-based peer perspectives presentation how she treats patients with hepatocellular carcinoma across the course of disease.