Metastasis-Free Survival Improved With Darolutamide in Nonmetastatic CRPC
February 16th 2019According to data from the phase III ARAMIS trial presented during the 2019 Genitourinary Cancers Symposium, darolutamide added to androgen deprivation therapy significantly improved metastasis-free survival compared with placebo plus ADT in patients with nonmetastatic castration-resistant prostate cancer.
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Updated Findings Show Sustained OS Benefit With Nivolumab/Ipilimumab Combo in Frontline RCC
February 14th 2019In updated 30-month follow-up data from the phase III CheckMate-214 trial, nivolumab combined with low-dose ipilimumab sustained strong responses and a survival benefit as a frontline treatment for patients with intermediate- and poor-risk advanced renal cell carcinoma.
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Hormonal Agents Lead to Improved Outcomes in African Americans With Chemo-Naive mCRPC
February 12th 2019Although African-American men are at a higher risk for metastatic castration-resistant prostate cancer and have worse survival outcomes compared with Caucasian men, findings of a recent retrospective study suggested they may have a better response to several prostate cancer treatments.
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Pembrolizumab Plus Axitinib Combination Demonstrates Survival Benefit in Frontline RCC
February 12th 2019Findings from the phase III KEYNOTE-426 study demonstrated a significantly improved progression-free survival and overall survival with the combination pembrolizumab plus axitinib versus sunitinib in previously-untreated patients with clear cell metastatic renal cell carcinoma, according to a prescast ahead of the 2019 Genitourinary Cancers Symposium.
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Promising Findings Seen With LuPSMA in Heavily Pretreated mCRPC
February 12th 2019Treatment with the novel targeted radiation therapy lutetium-177 PSMA-617 demonstrated strong clinical activity and the potential to improve survival in heavily pretreated men with PSMA-positive metastatic castration-resistant prostate cancer, according to phase II findings to be presented at the 2019 Genitourinary Cancers Symposium.
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Analysis Supports Association Between TKI Response and Longer OS in HCC
January 22nd 2019Achieving an objective response to TKI therapy was associated with longer overall survival in patients with previously untreated hepatocellular carcinoma, according to findings of a retrospective analysis presented during the 2019 Gastrointestinal Cancers Symposium.
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Promising CheckMate-142 Data for Second-Line Ipilimumab Plus Nivolumab in mCRC
January 22nd 2019Michael J. Overman, MD, discusses the data presented at the 2019 Gastrointestinal Cancers Symposium for the phase II CheckMate-142 in previously treated patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer.
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OS Increases With Checkpoint Inhibitor Doublet in Advanced Colorectal Cancer
January 21st 2019When durvalumab and tremelimumab were combined with best supportive care, the combination reduced the risk of progression or death by 28% compared with best supportive care alone, according to findings from a phase II clinical trial.
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Triplet Combo Improves Survival for BRAF V600E-Mutant mCRC
January 20th 2019Updated findings from the safety lead-in phase of the BEACON CRC trial showed an estimated survival time beyond historic controls from treatment with a triplet combination of encorafenib, binimetinib, and cetuximab for patients with <em>BRAF </em>V600E-mutant metastatic colorectal cancer.
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PFS Doubled With Regorafenib in Locally Advanced Biliary Tract Cancer
January 20th 2019Regorafenib reduced the risk of progression by 51% compared with placebo in patients with metastatic or unresectable biliary tract cancer who were previously treated with gemcitabine and platinum-based chemotherapy, according to results from the phase II REACHIN trial that were presented at the 2019 Gastrointestinal Cancers Symposium.
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BRAF V600E-Mutated Biliary Tract Cancer Benefits from BRAF/MEK Inhibition
January 19th 2019Combined BRAF and MEK inhibition induced a promising response rate and survival rates among patients with <em>BRAF </em>V600E–mutated biliary tract cancer (BTC), according to the results of the ROAR trial that were presented during the 2019 Gastrointestinal Cancers Symposium.
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OS Benefit From TAS-102 in Gastric Cancer Sustained in Subgroup Analysis
January 19th 2019Treatment with TAS-102 led to an improvement in overall survival among patients with metastatic gastric/gastroesophageal junction cancer. The improvement was also seen both in patients who had and had not undergone prior gastrectomy, according to a subgroup analysis from the phase III TAGS study.
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Next Steps After Phase III BEACON CRC Trial in mCRC
January 19th 2019Pashtoon M. Kasi, MD, MBBS, MS, discusses how the triplet regimen of the BRAF inhibitor encorafenib, the MEK inhibitor binimetinib, and the EGFR inhibitor cetuximab, will impact the treatment landscape for patients with metastatic colorectal cancer.
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Ramucirumab/Nivolumab Combination Active in Advanced Gastric Cancer
January 19th 2019Based on findings from the phase I/II NivoRam study, investigators at the 2019 Gastrointestinal Cancers Symposium reported that the combination of nivolumab and ramucirumab is active in patients with previously treated advanced gastric adenocarcinoma.
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Induction Regimen With Pembrolizumab/Trastuzumab Shows Benefit in HER2+ Gastric, GEJ Cancer
January 19th 2019In findings reported at the 2019 Gastrointestinal Cancers Symposium, 67% of patients with untreated metastatic HER2-positive esophagogastric adenocarcinoma treated with the combination of pembrolizumab, trastuzumab, and chemotherapy remained progression-free at 6 months.
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Pembrolizumab Demonstrates Survival Benefit in PD-L1+ Esophageal Cancer
January 18th 2019According to findings from the KEYNOTE-181 trial, pembrolizumab demonstrated a significant improvement in overall survival in patients with PD-L1–positive advanced or metastatic esophageal or esophageal junction carcinoma who progressed on standard therapy, marking the first time a PD-1 inhibitor has demonstrated a survival improvement in this patient population.
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Lower-Dose Tamoxifen Effective in Preventing Breast Cancer Recurrence
December 8th 2018Based on data from the phase III TAM-01 trial presented at the 41st Annual San Antonio Breast Cancer Symposium, investigators concluded that giving women diagnosed with breast intraepithelial neoplasia a lower dose of tamoxifen following surgery could be as effective and less toxic than the current standard dose.
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Impact of Pertuzumab in HER2-Positive Breast Cancer
December 8th 2018Charles E. Geyer, Jr, MD, professor of medicine at Virginia Commonwealth University School of Medicine, associate director for clinical research and Harrigan, Haw, Luck Families Chair in Cancer Research at Massey Cancer Center, discusses the impact of pertuzumab (Perjeta) in the treatment of patients with HER2-positive breast cancer at the 2018 San Antonio Breast Cancer Symposium.
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CTC Counts Hold Value in Therapy Selection for Metastatic Breast Cancer
December 7th 2018At the 2018 San Antonio Breast Cancer Symposium, data demonstrated that use of circulating tumor-cell counts had strong value for selecting endocrine therapy compared to chemotherapy in patients with estrogen receptor–positive, HER2-negative metastatic breast cancer.
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Response to Abemaciclib in the neoMONARCH Trial
December 7th 2018Sara A. Hurvitz, MD, director of the Breast Oncology Program, medical director of the Clinical Research Unit, University of California, Los Angeles Jonsson Comprehensive Cancer Center, discusses response to abemaciclib (Verzenio) in the neoMONARCH trial at the 2018 San Antonio Breast Cancer Symposium.
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PD-L1 Immune Cell Expression Identified as Predictor of Atezolizumab Benefit in TNBC
December 7th 2018A biomarker subgroup analysis of the phase III IMpassion130 study in patients with metastatic triple negative breast cancer or inoperable locally advanced TNBC found that progression-free survival and overall survival improvements with the addition of first-line atezolizumab to nab-paclitaxel were exclusive to patients with PD-L1 expression ≥1% in immune cells.
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Delaying Adjuvant Chemotherapy Linked to Worse Outcomes in TNBC
December 7th 2018Patients with triple-negative breast cancer who received chemotherapy treatment more than 30 days after surgery had worse survival rates and outcomes than patients who received adjuvant chemotherapy within 30 days of surgery, according to findings from a retrospective study presented at the 2018 San Antonio Breast Cancer Symposium.
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Identification of Patients With Luminal Androgen Receptor TNBC
December 6th 2018Roberto A. Leon Ferre, MD, oncologist, Mayo Clinic, discusses the identification of patients with luminal androgen receptor (LAR) triple-negative breast cancer (TNBC) during the 2018 San Antonio Breast Cancer Symposium.
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Adjuvant Capecitabine Fails to Provide Survival Benefit in Early-Stage TNBC
December 6th 2018Adding adjuvant capecitabine to the standard treatment for patients with early-stage triple-negative breast cancer did not lead to a significant improvement in disease-free or overall survival compared with observation, according to findings presented during the 2018 San Antonio Breast Cancer Symposium
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Achieving pCR After Neoadjuvant Chemo Linked to Improved Outcomes in Breast Cancer
December 6th 2018Patients with breast cancer who achieved pathologic complete response following neoadjuvant chemotherapy were more likely to have improved survival outcomes, according to findings of a meta-analyses data presented at the 2018 San Antonio Breast Cancer Symposium.
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KATHERINE Findings Support T-DM1 as New Adjuvant Standard in High-Risk HER2+ Breast Cancer
December 6th 2018Findings from the phase III KATHERINE study showed adjuvant treatment with ado-trastuzumab emtansine (T-DM1; Kadcyla) reduced the risk of invasive disease recurrence or death by 50% compared with trastuzumab (Herceptin) in patients with HER2-positive early breast cancer who had residual invasive disease following neoadjuvant therapy.
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Triplet Regimen Could Replace Standard of Care for Transplant-Ineligible Myeloma
December 5th 2018According to the phase III MAIA trial, triplet regimen daratumumab, lenalidomide, plus dexamethasone reduced risk of disease progression or death by 44% in newly diagnosed patients with multiple myeloma who were not candidates for high-dose chemotherapy and autologous stem-cell transplant, compared to patients who received lenalidomide plus dexamethasone.
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Selinexor Combo Sees Activity in Heavily Pretreated Penta-Refractory Myeloma
December 5th 2018An overall response rate of 26.2% was induced by selinexor, an oral XPO1 inhibitor, combination in heavily pretreated patients with penta-refractory multiple myeloma. According to the findings from part 2 of the pivotal STORM trial, selinexor is now the first investigational oral therapy to show activity in these patients.
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Consistent OS Benefit Seen Across Patient Subgroups With Quizartinib in AML
December 5th 2018An update on the pivotal phase III QuANTUM-R study presented at the 2018 ASH Annual Meeting demonstrated overall survival benefit across patient subgroups with quizartinib in patients with relapsed/refractory <em>FLT3</em>-ITD–mutated acute myeloid leukemia.
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