Benefit From MURANO Trial in CLL Sustained With Subsequent Therapy
December 9th 2020An analysis from the MURANO trial showed that venetoclax in combination with rituximab led to a more than doubling of time to next treatment compared with bendamustine and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia.
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Higher CPX-351 Induction Doses Lead to Delayed Hematologic Recovery in AML
December 8th 2020Treatment with higher doses of CPX-351 in younger patients with newly diagnosed high-risk or secondary acute myeloid leukemia was significantly associated with prolonged hematologic recovery times during induction cycles 1 and 2.
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Results of Selinexor Added to Pd Regimen Moves Myeloma Study on to Phase 3
December 8th 2020The combination of selinexor plus pomalidomide and low-dose dexamethasone led to favorable responses in a cohort of patients with heavily pretreated multiple myeloma, warranting further investigation of the regimen in a phase 3 trial.
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Brentuximab Vedotin Tolerable With High Response Rates in Older Patients with cHL
December 8th 2020In older patients with comorbid classical Hodgkin lymphoma who are deemed unfit for combination chemotherapy, treatment with the antibody dug conjugate brentuximab vedotin appeared tolerable and achieved high response rates that were durable in some patients, according to results from the phase 2 SGN35-015 study.
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REACH3 Study Demonstrates Promising Objective Responses in Chronic GVHD
December 8th 2020Robert Zeiser, MD, discusses the findings from the phase 3 REACH3 clinical trial of ruxolitinib as treatment of patients with chronic graft-versus-host disease with an inadequate response to corticosteroids.
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Significant Responses Seen With Investigational BTK Inhibitor in Pretreated CLL/SLL Population
December 8th 2020A high objective response rate was observed in patients with chronic lymphocytic leukemia and small lymphocytic lymphoma treated with LOXO-305, according to results of the phase 1/2 BRUIN trial presented during the 2020 ASH Annual Meeting.
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Added Daratumumab Leads to Significant Hematologic Responses in Amyloidosis
December 8th 2020Results for the phase 3 ANDROMEDA study showed an improvement in hematologic complete response rates with the combination of daratumumab plus bortezomib, cyclophosphamide, and dexamethasone compared with VCd alone in patients with newly diagnosed amyloid light-chain amyloidosis.
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Liso-Cel Achieves High MRD Negativity Rate in High-Risk CLL/SLL
December 8th 2020Chimeric antigen receptor T-cell therapy with lisocabtagene maraleucel led to rapid and durable responses in patients with high-risk relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.
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Ponatinib Demonstrates Efficacy Over Time for Patients With CP-CML After Prior TKI Failure
December 7th 2020High response rates and robust survival outcomes among patients with chronic-phase chronic myeloid leukemia who failed prior treatment with a second-generation tyrosine kinase inhibitor were observed in 2 clinical trials of ponatinib,.
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A 20-mg 3-times-weekly or twice-weekly dosing schedule of panobinostat combined with subcutaneous bortezomib plus dexamethasone induced durable responses as treatment of patients with relapsed or refractory multiple myeloma and demonstrated an acceptable safety profile in the phase 2 PANORAMA 3 study.
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Immunotherapy Treatment Improves Survival Among Adults With ALL After HCT Relapse
December 7th 2020Adult patients with acute lymphoblastic leukemia who have relapsed following hematopoietic cell transplantation have experienced considerably improved survival benefits over the past few years, which may be due to an increased use of immunotherapy.
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Luspatercept Demonstrates Efficacy and Tolerable Safety in Patients With MDS/MPN-RS-T
December 7th 2020Luspatercept demonstrated clinical efficacy and a tolerable safety profile in patients with myelodysplastic syndrome/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis who were enrolled in the MEDALIST trial.
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Daratumumab Regimen Shows Promise in Transplant-Eligible Patients With Newly Diagnosed Myeloma
December 7th 2020The combination of daratumumab with lenalidomide, bortezomib, and dexamethasone followed by maintenance therapy with daratumumab and lenalidomide improved response rates and depth of response rates with statistically significance as treatment of patients with transplant-eligible newly diagnosed multiple myeloma.
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Ublituximab Doublet Bests Chemoimmunotherapy in Chronic Lymphocytic Leukemia
December 7th 2020In the phase 3 UNITY-CLL study, ublituximab in combination with umbralisib demonstrated synergistic activity in patients with chronic lymphocytic leukemia compared with standard of care chemoimmunotherapy irrespective of prior treatment.
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Pooled Analysis Supports Use of Acalabrutinib in Patients With Chronic Lymphocytic Leukemia
December 7th 2020Jennifer R. Brown, MD, PhD, discusses the implications of the findings from a pooled analysis of cardiovascular events from studies of the next-generation BTK inhibitor acalabrutinib monotherapy as treatment of patients with chronic lymphocytic leukemia.
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Subcutaneous Daratumumab Triplet Improves PFS in R/R Multiple Myeloma
December 7th 2020In the phase 3 APOLLO study, patients with relapsed/refractory multiple myeloma who had received 1 or more prior line of therapy had a significantly reduced the risk of progression or death by 37% when treated with the combination of subcutaneous daratumumab to pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone.
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Clinically Meaningful HRQoL Benefits Observed With Ide-Cel in Triple-Class Exposed R/R Myeloma
December 7th 2020Idecabtagene vicleucel demonstrated clinically meaningful improvements in the quality-of-life of triple-class exposed patients with relapsed/refractory multiple myeloma in the phase 2 KarMMA trial.
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Odronextamab Shows Intriguing Antitumor Activity in Relapsed/Refractory B-Cell NHL
December 6th 2020Promising antitumor activity, as well as an acceptable safety profile, continues to be demonstrated with odronextamab, a novel CD20xCD3 bispecific antibody, as treatment of patients with relapsed/refractory B-cell non-Hodgkin lymphoma.
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Novel CELMoD Agent Demonstrates Early Promise in Relapsed/Refractory Myeloma
December 6th 2020The novel oral cereblon E3 ligase modulator agent CC-92480 in combination with dexamethasone was found to be pharmacologically active with immunomodulatory activity at all doses as treatment of patients with relapsed/refractory multiple myeloma.
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Orca-T Shows Preventative Potential for GVHS in High-Risk Blood Cancers
December 6th 2020The precision Treg-engineered donor product Orca-T exhibited preventive potential for graft-versus-host disease in patients with high-risk hematologic malignancies who underwent hematopietic stem cell transplantation, with less immunosuppression compared with the standard of care.
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Health-Related QoL Improvements Observed in R/R Multiple Myeloma After Cilta-Cel
December 6th 2020Patients with relapsed/refractory multiple myeloma treated with ciltacabtagene autoleucel experienced rapid and clinically meaningful improvements in health-related quality of life and trends suggested that HRQoL benefits may be greater as responses to therapy deepen over time.
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High-/Low-Dose Sabatolimab Exhibit Comparable Pharmacokinetics in MDS and AML
December 6th 2020In patients with acute myeloid leukemia and myelodysplastic syndrome, treatment with sabatolimab administered at 200 mg every 2 weeks and 800 mg every 4 weeks demonstrated similar pharmacokinetic activity, according to findings from a dose-selection and dose-response analysis presented during the 2020 American Society of Hematology Annual Meeting.
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