Use of Axi-Cel in Previously Excluded LBCL Populations Supported by Real-World Evidence
December 13th 2021While Axicabtagene ciloleucel demonstrated favorable efficacy in elderly patients and those with other comorbidities with large B-cell lymphoma, adverse events were common in some of these populations.
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In Older Patients With Chronic Lymphocytic Leukemia Ibrutinib Regimens Yield Superior Efficacy
December 13th 2021Compared to those who received rituximab and bendamustine, elderly patients treated with ibrutinib-containing regimens for chronic lymphocytic leukemia saw a progression-free survival benefit.
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Implications of the SEQUOIA Trial Results of Zanubrutinib/Venetoclax in CLL/SLL
December 13th 2021Jennifer R. Brown, MD, PhD, discusses the implications of the SEQUOIA trial, which looked at the combination of zanubrutinib and venetoclax for the treatment of patients with treatment-naïve chronic lymphocytic leukemia or small lymphocytic lymphoma.
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Cilta-cel Demonstrates Significant Advantage Over SOC in Triple-Class R/R Myeloma
December 13th 2021A CARTITUDE-1 meta-analysis data shows that ciltacabtagene autoleucel performs better than standard-of-care therapy in terms of survival and response rates in patients with triple-class relapsed/refractory multiple myeloma.
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IPSS and JAK2 Status Could Predict Thrombosis Risk in Primary Myelofibrosis
December 12th 2021Analysis shows that International Prognostic Scoring System score and the presence of a JAK2 mutation was linked to risk of thrombosis in patients with primary myelofibrosis. Investigators observed a benefit for ruxolitinib in patients.
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MRD Assessment in Newly Diagnosed Multiple Myeloma Can Guide Therapy Choice
December 12th 2021Minimum residual disease can inform approaches to treatment of newly diagnosed multiple myeloma for patients receiving daratumumab plus carfilzomib, lenalidomide, and dexamethasone following autologous transplant.
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Venetoclax With Acalabrutinib or Obinutuzumab Evaluated in Treatment-Naive CLL/SLL
December 12th 2021In a randomized phase 3 trial, acalabrutinib plus venetoclax versus obinutuzumab plus venetoclax will be investigated for efficacy and safety with a noninferiority design in patients with previously untreated chronic lymphocytic leukemia/small lymphocytic leukemia.
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Prolonged, Deeper Molecular Responses Produced by Asciminib in Chronic-Phase CML
December 12th 2021Findings from the phase 3 ASCEMBL trial showed a consistent improvement in major molecular response rate and depth of response without any new or worsening adverse effects when treating with asciminib versus bosutinib in patients with chronic-phase chronic myeloid leukemia.
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Real-World Study of Tisagenlecleucel in R/R B-Cell Non-Hodgkin Lymphomas Shows Efficacy, Safety
December 12th 2021Real-world data on tisagenlecleucel in patients with relapsed/refractory B-cell lymphoma was consistent with the phase 2 JULIET trial, demonstrating favorable efficacy and safety.
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Encouraging Results Seen with Selinexor and D-Vd in Relapsed/Refractory Multiple Myeloma
December 12th 2021Patients with late- and early-relapsed multiple myeloma receiving the combination of selinexor plus daratumumab, bortezomib, and dexamethasone showed promising efficacy and a manageable safety profile.
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