Evaluating XPO1 Inhibitors in Multiple Myeloma and their Potential Role in Myelofibrosis

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Expert hematologist-oncologists share insight on the evolving role of XPO1 inhibitor therapy in the management of multiple myeloma and myelofibrosis.

Overview of Relapsed/Refractory Multiple Myeloma

EP. 1: Overview of Relapsed/Refractory Multiple Myeloma

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Joshua Richter, MD, gives an overview of relapse/refractory multiple myeloma and the available treatment options.

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Mechanism of Action of Selinexor and its Role in Multiple Myeloma

EP. 2: Mechanism of Action of Selinexor and its Role in Multiple Myeloma

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Dr Joshua Richter describes the mechanism of action of XPO1 inhibitor selinexor and its use in treating multiple myeloma.

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Selinexor in Multiple Myeloma: Review of Clinical Trial Data

EP. 3: Selinexor in Multiple Myeloma: Review of Clinical Trial Data

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Joshua Richter, MD, reviews data from two clinical trials investigating selinexor combination therapies for the treatment of multiple myeloma.

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Overview of Triple Class Refractory Multiple Myeloma

EP. 4: Overview of Triple Class Refractory Multiple Myeloma

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Dr Joshua Richter explains triple class refractory myeloma and the need for more data on treatment options.

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Updates on Selinexor Triplet Combination Therapies from ASH 2022

EP. 5: Updates on Selinexor Triplet Combination Therapies from ASH 2022

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Joshua Richter, MD, highlights key data from an update to a study investigating a selinexor triplet combination therapy.

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Determining Which Patients With Multiple Myeloma are Candidates for Triplet Combination Therapies

EP. 6: Determining Which Patients With Multiple Myeloma are Candidates for Triplet Combination Therapies

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Dr Joshua Richter explains which patients with multiple myeloma are most suitable for triplet combination therapies.

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Defining Myelofibrosis and Identifying Clinical Symptoms

EP. 7: Defining Myelofibrosis and Identifying Clinical Symptoms

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Srdan Verstovsek, MD, provides an overview of myelofibrosis and the clinical signs and symptoms to look for.

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The JAK-STAT Pathway in the Treatment of Myelofibrosis

EP. 8: The JAK-STAT Pathway in the Treatment of Myelofibrosis

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Dr Srdan Verstovsek, MD, details how the JAK-STAT pathway is utilized in the treatment of myelofibrosis.

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Combination Ruxolitinib and Selinexor for the Treatment of Naïve Myelofibrosis

EP. 9: Combination Ruxolitinib and Selinexor for the Treatment of Naïve Myelofibrosis

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Srdan Verstovsek, MD, reviews data presented at ASH 2022 on combination ruxolitinib and selinexor for the frontline treatment of myelofibrosis.

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The Role of Ruxolitinib in Myelofibrosis Treatment

EP. 10: The Role of Ruxolitinib in Myelofibrosis Treatment

Joshua Richter, MD;Srdan Verstovsek, MD, PhD
January 30th 2023

Dr Srdan Verstovsek discusses how ruxolitinib might fit into the myelofibrosis treatment landscape in the future, and highlights remaining unmet needs.

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