Therapeutic Sequencing for Relapsed/Refractory Metastatic Renal Cell Carcinoma: The Case of a 65-year-old Patient
Pedro Barata, MD, MSc, FACP, discussessequencing for a relapsed/refractory metastatic renal cell carcinoma patient case. He also discusses how third-line mRCC therapy aims for disease control and symptom palliation with careful toxicity management. Options include cabozantinib, lenvatinib/everolimus, and tivozanib, with selection based on prior therapy, comorbidities, and tolerability.
EP. 1: Case 2: Patient With Relapsed/Recurrent Metastatic RCC
February 27th 2025An expert discusses the patient case of a 65-year-old woman who has presented to the emergency department with abdominal pain. The patient’s previous medical issues include a duodenal ulcer that she experienced 10 years ago. The patient is a smoker, and her current medication is lansoprazole (30 mg). After the patient begins to present worsening lower back pain, a CT scan shows lytic lesions in her thoracic spine and rounded lesion in both lungs. A biopsy of the lung lesion confirms clear cell renal cell carcinoma (RCC) with sarcomatoid differentiation.
Watch
EP. 2: Treatment Goals for Transitioning From 2L to 3L mRCC
February 27th 2025An expert discusses how, in third line (3L) therapy, goals shift from optimal disease control to managing treatment-resistant disease while preserving quality of life. Unlike 2L therapy where significant disease control is still expected, 3L aims for modest clinical benefit, symptomatic relief, and stabilizing disease progression. Treatment choices now heavily prioritize tolerability, patient preferences, and palliative considerations.
Watch
