A 59-Year-Old Man With Relapsed Follicular Lymphoma

Video

A 59-Year-Old Man With Relapsed Follicular Lymphoma

Case: A 59-Year-Old Man With Symptomatic Follicular Lymphoma

A 59-year-old man presented to his physician with a 10-lb weight loss and chronic night sweats for the past couple of months. He complained of intermittent fatigue but is able to maintain his current exercise regimen.

H & P

  • PE: enlarged bilateral axillary lymph nodes; enlarged spleen, palpable
  • CBC: WBC, 12 X 104/L; platelets,103 X 109/L; Hgb, 9.2 g/dL
  • LDH: 400 U/L

Biopsy

  • Excisional biopsy showed grade 2 follicular lymphoma; CD20+, CD10+
  • Bone marrow biopsy; 60% involved

Imaging

  • PET/CT showed widespread lymphadenopathy and a large splenic mass measuring 10 cm
  • Diagnosis: Stage IV follicular lymphoma

Teatment

  • Started on R-CHOP; tolerated induction well
  • Post-therapy PET showed partial remission
  • Followed by Rituximab maintenance until evidence of disease progression

Follow-up

  • Core needle biopsy; performed confirmed persistent follicular lymphoma; no transformation
  • PET at 12 months showed increased size of splenic mass
  • ECOG, 0
  • Patient started on obinutuzumab + bendamustine
Recent Videos
Jamie L. Koprivnikar, MD, an expert on MDS
Jamie L. Koprivnikar, MD, an expert on MDS
Jamie L. Koprivnikar, MD, an expert on MDS
Jamie L. Koprivnikar, MD, an expert on MDS
Jamie L. Koprivnikar, MD, an expert on MDS
Jamie L. Koprivnikar, MD, an expert on MDS
Jamie L. Koprivnikar, MD, an expert on MDS
Jamie L. Koprivnikar, MD, an expert on MDS
Solly Chedid, MD, an expert on MDS
Solly Chedid, MD, an expert on MDS
Related Content