Abdullah M. Khan, MBBS, discusses the recent updates to data on the use of idecabtagene vicleucel in patients with relapsed/refractory multiple myeloma.
Abdullah M. Khan, MBBS, assistant professor in the division of hematology at The Ohio State University Comprehensive Cancer Center – The James, discusses the recent updates to data on the use of idecabtagene vicleucel (ide-cel; Abecma) in patients with relapsed/refractory multiple myeloma.
Updated data from the pivotal phase 3 KarMMa-3 trial (NCT03651128), which led to the approval of this chimeric antigen receptor T-cell therapy, were reported at the 2023 American Society of Hematology Annual Meeting & Exposition. At a follow-up of 30.9 months, investigators reported interim overall survival (OS) data, showing that the median OS was 41.4 months with ide-cel vs 37.9 months in the standard therapy group.
Additionally, Khan noted that real-world evidence with ide-cel was reported in the Journal of Clinical Oncology in 2023, supporting its use in patients who do not necessarily match the stringent patient eligibility requirements of a clinical trial. For the 159 patients who received ide-cel, the best overall response rate was 84% and median progression-free survival (PFS) was 8.5 months (95% CI, 6.5-not reached), whereas median OS was 12.5 months (95% CI, 11.3-not reached).
According to Khan, these are both promising sources of data showing the benefit of ide-cel including in patients with comorbidities who are treated with CAR T-cell therapy in the real world.
TRANSCRIPTION:
0:08 | I wanted to give a little bit of updated data from the ASH 2023 conference. We actually have survival data for the KarMMa-3 trial with a longer follow-up of about 31 months. What they were able to show was the median OS in the ide-cel group was 41.4 months vs 37.9 months in the standard [therapy] group.
0:38 | There was also recent publication talking about ide-cel in the real world. Real world means that inclusion and exclusion criteria that are pretty stringent in trial design, we're applying less of those rules toward the patients we see in our clinic. And in a recent publication in JCO in 2023, in 159 patients, what they showed was response rates were also very impressive, about 84%. …In these less ideal patients…in terms of trial candidacy, median PFS was 8.5 months, and the median OS was 12.5 months. Again, very promising data, not just in the trial, but also real-world data.
NGS and ctDNA Considered in Advanced Breast Cancer After Progression
May 3rd 2024During a Case-Based Roundtable® event, Ruth M. O'Regan, MD, led a discussion on whether to order next-generation sequencing and/or circulating tumor DNA testing for a patient with hormone receptor–positive breast cancer after progression in the first article of a 2-part series.
Read More
Landgren on MRD as an End Point for Multiple Myeloma Trials
May 1st 2024C. Ola Landgren, MD, PhD, discussed the FDA’s unanimous ODAC vote supporting minimal residual disease as an accelerated approval end point in multiple myeloma and the implications of this vote in the myeloma research field.
Read More
Tolerability Helps Decide Third-Line Treatment in Advanced RCC
April 30th 2024During a Case-Based Roundtable® Chandler H. Park, MD, led a discussion on the considerations physicians have when deciding on their treatment approach in the third line for patients with advanced renal cell carcinoma in the first article of a 2-part series.
Read More
Intracranial Response Data Supports Use of Brigatinib in ALK+ NSCLC
April 26th 2024During a Case-Based Roundtable® event, Yasir Y. Elamin, MD, discussed the intracranial efficacy of brigatinib from the ALTA-1L trial for patients with ALK+ non–small cell lung cancer in the first article of a 2-part series.
Read More