Obesity and Menopausal Status in Breast Cancer
Clifford A. Hudis, MD, discusses obesity and menopausal status as determinants of procarcinogenic breast inflammation.
Clinical Pearls
Clifford A. Hudis, MD, Chief, Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, professor of medicine, Weill Cornell Medical College, discusses obesity and menopausal status as determinants of procarcinogenic breast inflammation.
- The peak incidence of hormone-sensitive breast cancer occurs in the decade after menopause.
- There is an association between hormone-sensitive breast cancer and obesity.
- Some of the inflammatory mediators that are generated in the fat tissue of obese patients are stimulants for the production of aromatase, and thereby, estrogen.
- Predictors of these inflammatory mediators in the breast include both obesity and the postmenopausal state. This suggests that after menopause, there is a low-grade, chronic systemic inflammation in some people that may contribute to postmenopausal breast cancer.
<<<
Breast Cancer Leans into the Decade of Antibody-Drug Conjugates, Experts Discuss
September 25th 2020In season 1, episode 3 of Targeted Talks, the importance of precision medicine in breast cancer, and how that vitally differs in community oncology compared with academic settings, is the topic of discussion.
Listen
HER2-Low and -Ultralow Populations Benefit from T-DXd in HR+ mBC
November 13th 2024During a Case-Based Roundtable® event, Aditya Bardia, MD, MS, FASCO, discussed data from the DESTINY-Breast04 and DESTINY-Breast06 trials for HER2-low breast cancer in the second article of a 2-part series.
Read More
