Infigratinib Findings in Subset of IHC Emphasize Importance of Molecular Testing

Milind Javle, MD

Milind Javle, MD

The selective pan-FGFR kinase infigratinib demonstrated a manageable toxicity profile and clinically meaningful activity following chemotherapy in patients with intrahepatic cholangiocarcinoma (IHC), according to updated phase II findings presented at the 2018 ESMO Congress.

The multicenter, open-label study enrolled patients withFGFRfusions (n = 71), which occur in approximately 13% to 17% of patients with IHC. Lead study author Milind Javle, MD said this is one of the first studies to target patients with IHC by actionable mutations.

Results showed that the overall response rate (ORR) was 31.5% (95% CI, 20.5%-43.1%), and the investigator-assessed ORR was 26.9% (95% CI, 16.8%-39.1%). The disease control rate was 86.9%, with a median duration of response of 5.4 months. Moreover, the median progression-free survival (PFS) and overall survival (OS) were 6.8 months (95% CI, 5.8-7.6) and 12.5 months (9.9-16.6), respectively.

In an interview withTargeted Oncology,Javle, professor, Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discussed the findings from this phase II study and emphasized the importance of molecular testing in cholangiocarcinoma.

TARGETED ONCOLOGY:Could you begin with some background on this drug and the phase II trial?

Javle:The molecular profiling of cholangiocarcinoma is transforming this disease, as it has more actionable mutations than most other gastrointestinal cancers. We began this FGFR-directed trial close to 5 years ago, we really thought that this would be a difficult trial to implement because there has never been a targeted therapy trial in cholangiocarcinoma against a specific genetic mutation.FGFRfusions occur in about 15% of IHC. It is a rare subset in a rare disease. We thought this would be hard to do, but we finished the enrollment in less than 2 years.

In general, patients with cholangiocarcinoma receive first-line chemotherapy with gemcitabine or cisplatin. In the second-line setting, there are very few options, and the progression-free survival (PFS) is usually 3 months with standard therapy, such as capecitabine, 5-fluorouracil or FOLFOX. Unfortunately, these patients have pretty poor outcomes and there are quality-of-life (QoL) issues with second-line chemotherapy.

With this trial, we showed that the PFS was close to 6 months, and we noticed that the original response rate was much lower. It has now increased to more than 25%. As these patients are followed longer, overall response rate rises due to delayed responses. The overall survival is close to 1 year from the time that patients were enrolled.

This study has taught us a lot about this disease. First, [it taught us] that FGFR fusions occur in 15% of patients, but more so in the younger population and often in women. These patients do benefit with targeted FGFR inhibition. The vast majority of patients either have response or stable disease. The disease control rate was 80%, so that is quite remarkable for a targeted therapy in this disease.

TARGETED ONCOLOGY:Based on the findings thus far, are there any next steps?

Javle:The next step here is to see whether we can expand this experience in the first-line setting, where this drug can be given upfront without chemotherapy. I believe that the efficacy will be seen in the first-line setting as well.

In our study, we showed that whether you give second- or a subsequent line of therapy, the PFS did not really change, although the response rate was a little higher if the patient had received 1 prior line of therapy versus several lines. I am hoping that eventually, we may show that these patients can be treated with FGFR-targeted therapy without the need for chemotherapy. Currently, this is the largest trial of patients with FGFR fusions, and it also has the longest follow-up.

TARGETED ONCOLOGY:You mentioned that molecular testing is very important in this subset of patients. What is the prevalence of molecular testing for patients diagnosed with cholangiocarcinoma?

Javle:We believe that next-generation sequencing (NGS) and molecular testing should be the standard for cholangiocarcinoma. With the advent of immunotherapy for microsatellite instability-high patients, and with these newer targeted therapies, [molecular testing] opens the door for successful treatments. Unfortunately, it is still not standard of care in most parts of the world, including the United States. Outside of major academic centers, providers do not routinely request NGS.

When we looked at our series of more than 500 patients with cholangiocarcinoma, we found that even when you try to do it in all patients, only about 40% of patients have adequate tissue for NGS. You need a large core biopsy and adequate viable DNA. The yield of NGS is higher in IHC, where it is about 60%. In extrahepatic IHC, the tissue is often very low, so it is more like 20%.

On average, 40% of patients have adequate tissue for sequencing. But as technology develops, we are going to be able to get molecular information with blood biopsies and cytology specimens. Our hope is that eventually, all patients will have this valuable tool for understanding the underlying genetics that may have value both for prognosis as well as predictive value for targeted therapies.

TARGETED ONCOLOGY:What is your take-home message from the findings of this trial thus far?

Javle:The bigger picture is that this trial highlights the role of molecular profiling. We believe at this point, that 40% to 50% of patients with cholangiocarcinoma have actionable mutations. If you can capture that population with universal molecular testing for all patients, then I suspect we will see the decrease in use of systemic chemotherapy and its consequent toxicity, and more use of targeted therapies based on underlying profile. That will transform the treatment of this cancer, and improve patients’ QoL.

This is an exciting time for cholangiocarcinoma research, there is great traction and interest from pharmaceutical companies due to these targets that we have found with molecular profiling. This disease is not what it used to be 10 years ago. It is a much more treatable disease, and we hope that eventually, we can impact the outcome of these patients in a very significant manner.

Reference:

Javle M, Kelley RK, Roychowdhury S, et al. A phase II study of infigratinib (BGJ398), an FGFR-selective tyrosine kinase inhibitor (TKI), in patients with previously-treated advanced cholangiocarcinoma containing FGFR2 fusions. In: Proceedings from the 2018 ESMO Congress; October 19-23, 2018; Munich, Germany. Abstract 3652.