Early Data Presented for Lenvatinib and Pembrolizumab in Thyroid Cancer
Christine Dierks, MD, discusses the early data from a study looking at the combination of lenvatinib and pembrolizumab in patients with metastatic anaplastic or poorly differentiated thyroid carcinoma.
Christine Dierks, MD, senior physician at the University Hospital Freilburg in Germany, discusses the early data from a study looking at the combination of lenvatinib (Lenvima) and pembrolizumab (Keytruda) in patients with metastatic anaplastic or poorly differentiated thyroid carcinoma.
This trial was the same drug combination and patient population as the phase 2 ATLEP study that Dierks was a part of. Similarly, patients had previously treated disease with multiple therapies, such as chemotherapy, except for lenvatinib and pembrolizumab.
At the European Society of Medical Oncology (ESMO) Virtual Congress 2020, the data for the first 20 patients after 3 months was presented and the rest will not come out for a long period of time, according to Dierks. The response rate after 3 months was 30% and the best overall for patients was 50%, including some patients who are 9 months into the regimen. She says the overall response is slowly improving over time as patients go further on therapy.
The time to response with the combination is slow and complete remission rates were seen in 8 patients and the first complete remission was seen after 11 months of treatment. Dierks believes that patients have to stay on therapy for a long period of time to achieve complete response.
Advancing Neoadjuvant Therapy for HER2+ Breast Cancer Through ctDNA Monitoring
December 19th 2024In an interview with Targeted Oncology, Adrienne Waks, MD, provided insights into the significance of the findings from the DAPHNe trial and their clinical implications for patients with HER2-positive breast cancer.
Read More
Anticipating Novel Options for the RAI-Refractory DTC Armamentarium
May 15th 2023In season 4, episode 6 of Targeted Talks, Warren Swegal, MD, takes a multidisciplinary look at the RAI-refractory differentiated thyroid cancer treatment landscape, including the research behind 2 promising systemic therapy options.
Listen
AI-Driven Deep Learning Model Shows Promise in Standardizing MDS Diagnosis
December 10th 2024In an interview, Palak Dave discussed how artificial intelligence, using deep learning to analyze bone marrow aspirate smear images, could standardize and accelerate the diagnosis of MDS vs pre-MDS conditions.
Read More
Systemic Therapy Choice Linked to Radiosurgery Outcomes in Brain Mets
December 6th 2024In an interview with Targeted OncologyT, Rupesh Kotecha, MD, discussed a study focused on how systemic therapy selection impacts outcomes in patients with brain metastases, particularly those with lung cancer.
Read More
Post Hoc and Real-World Analyses Explore Benefit of Lenvatinib in DTC
December 5th 2024During a Case-Based Roundtable® event, Lori J. Wirth, discussed recent analyses that have developed a better understanding of the outcomes with lenvatinib in differentiated thyroid cancer in the second article of a 2-part series.
Read More
