Dr. Safi Shahda on a Phase Ib Study Investigating BBI-608 for mPDAC
"This combination seems to be well-tolerated by patients with manageable toxicity, and overall efficacy for the small group seems to be favorable."
Safi Shahda, MD, assistant professor of Clinical Medicine, Indiana University School of Medicine, discusses a phase Ib study looking at a combination of BBI-608, gemcitabine, and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC). Shahda says so far, 8 patients from the study have been reported on in terms of efficacy and 18 patients have been reported on in terms of safety. He adds that the combination thus far appears to be tolerable with manageable toxicities.
Ilson Examines Chemoimmunotherapy Regimens for Metastatic Gastroesophageal Cancers
December 20th 2024During a Case-Based Roundtable® event, David H. Ilson, MD, PhD, discussed the outcomes of the CheckMate 649, CheckMate 648, and KEYNOTE-859 trials of chemoimmunotherapy regimens in patients with upper GI cancers.
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ctDNA Detection Tied to Tumor Burden, Recurrence in HR+ Early Breast Cancer
December 13th 2024A phase 2 trial showed ctDNA detection in HR-positive early breast cancer was linked to larger tumors, higher residual cancer burden, and increased recurrence after neoadjuvant endocrine therapy.
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