Expert physicians discuss the rationale behind the clinical use of JAK inhibitors in acute GvHD (graft-versus-host disease), and provide an overview of recent clinical trial data for this treatment approach.
EP. 1: Janus Kinase Signaling Role in Pathogenesis of GvHD
A discussion on the role on Janus kinase signaling in the pathogenesis of acute and chronic graft-vs-host disease (GVHD).
Watch
EP. 2: JAK Inhibitor Efficacy in Steroid Refractory GVHD
Expert physicians discuss the role and efficacy of JAK inhibitors in steroid-refractory graft-vs-host disease (GVHD).
EP. 3: First-Line Steroid Treatment Goals in Acute GVHD
Key opinion leaders discuss treatment goals for frontline therapy in patients with acute graft-vs-host disease.
EP. 4: Phase III REACH2 Study Overview
A discussion on decision factors for switching to and deciding upon a second-line therapy, and an overview of the phase 3 REACH2 study with ruxolitinib for glucocorticoid-refractory acute graft-vs-host disease (GVHD).
EP. 5: Practical Advice for Implementing the REACH2 Regimen
Key opinion leaders provide community oncologists with advice for implementing the REACH2 regimen to manage patients with acute graft-vs-host disease (GVHD).
EP. 6: The Promising Future of GVHD Management
Expert physicians consider how ongoing developments will impact the treatment paradigm of graft-vs-host disease.
EP. 7: ASH 2020 Clinical Trial Data
A discussion on upcoming clinical trial data presentations featured at the American Society of Hematology (ASH) 2020 Annual Meeting.
EP. 8: Acute GVHD Prophylaxis Protocol
Key opinion leaders close the discussion by providing insight into their respective protocols for acute graft-vs-host (GVHD) disease prophylaxis.