News

The NovoTTF-100L System has received approval from the FDA in combination with pemetrexed and platinum-based chemotherapy as a frontline treatment for patients with unresectable, locally advanced or metastatic malignant pleural mesothelioma.

Raajit K. Rampal, MD, PhD, discusses a retrospective analysis of pre-transplant samples from patients with MF to determine the value of mutational profiling in predicting outcomes after transplant.

The combination of encorafenib, binimetinib, and cetuximab reduced the risk of death by 48% in patients wtih&nbsp;<em>BRAF</em> V600E-mutant metastatic colorectal cancer who have received up to 2 prior lines of therapy compared with cetuximab and irinotecan-containing regimens, according to the phase III BEACON CRC trial, which met both its primary endpoints.

Arjun V. Balar, MD,&nbsp;highlights the KEYNOTE-057 study findings and provides insight into the role of immunotherapy in bladder cancer.

Mark Socinski, MD, explained to a group of physicians at a recent <em>Targeted Oncology </em>live case-based peer perspectives presentation the treatment considerations and decisions he makes when seeing patients with non&ndash;small cell lung cancer in the clinic.

Rozita Yarmand, PhD, discusses the rationale for investigating ONC201 in patients with medullary thyroid cancer and the toxicity profile that has been seen with this small molecule in mouse models and in other tumor types.

Pashtoon M. Kasi, MD, MBBS, MS, discussed&nbsp;the current role of liquid biopsies in patients with CRC, GI, and other types of cancers. He also highlights the advantages to making treatment decisions based on results from liquid biopsies.

Robert L. Ferris, MD, PhD,&nbsp;co-physician editor-in-chief of <em>Targeted Therapies in Oncology</em>, highlights&nbsp;a series of exciting results presented across various topics, which affect cancer research and treatment, during the 2019 AACR Annual Meeting.

Emil Cohen, MD,&nbsp;discusses the locoregional therapies available for the treatment of patients with HCC and offers insight into optimal strategies.

A new report published in<em> Leukemia Research</em> found that results from the lead-in cohort of an open-label phase lb/II trial of glasdegib in patients with primary or secondary myelofibrosis previously treated with at least 1 JAK inhibitor indicated acceptable safety and tolerability.

Pembrolizumab monotherapy missed the prespecified primary endpoint of superior overall survival compared to chemotherapy in the phase III KEYNOTE-119 trial, in which the PD-1 inhibitor was being investigated as a second- or third-line treatment for patients with metastatic triple-negative breast cancer.

Jennifer Geurts, MS, CGC,&nbsp;discusses the current role of genetic testing, both in patients diagnosed with cancer, as well as family members that could be at risk of developing cancer. She also highlights how genetic counseling can impact treatment decisions in patients with pancreatic, breast, and ovarian cancers.

Investigators on a first-in-human phase I trial found that antibody and T-cell responses were detected in a vaccine targeting&nbsp;GUCY2C, a commonly overexpressed protein in patients with early-stage colorectal cancer.<br /> &nbsp;

Preclinical data suggest that the small molecule IACS-10759, which targets the oxidative phosphorylation and glutaminolysis pathways, may play a critical role in overcoming resistance to ibrutinib in mantle cell lymphoma.

Geoffrey R. Oxnard, MD,&nbsp;discusses testing error underlying liquid biopsy discordance. He also highlights steps clinicians can take to optimize liquid biopsies and where he sees this evolving in the treatment landscape for patients with cancer.

During a recent <em>Targeted Oncology </em>live case-based peer perspectives presentation, Paul K. Paik, MD, explained to a group of physicians the treatment considerations and decisions he makes when seeing a patient with non&ndash;small cell lung cancer.

According to results from a phase IIIb interim analysis, afatinib demonstrated a predictable and manageable toxicity profile and promising efficacy in patients with <em>EGFR</em> mutation-positive non&ndash;small cell lung cancer.

A new single-center report published in&nbsp;<em>JCO Precision Oncology&nbsp;</em>offers a proof of concept for using circulating tumor DNA to guide clinical decisions in high-grade serous ovarian cancer.&nbsp;

In the first precision oncology trial for pediatric patients with cancer, a larger percentage of patients than expected who underwent screening for targetable alterations in their tumors were able to be assigned to a treatment targeted to that alteration or pathway.

Lenalidomide induced a 72% reduction in the risk of progression to symptomatic disease in patients with smoldering multiple myeloma at 3 years, according to data from the ECOG E3A06 study, to be presented during the 2019 ASCO Annual Meeting.

Comparable efficacy and minimized adverse events were seen with a lower dose of&nbsp;oxaliplatin (Eloxatin) and capecitabine (Xeloda)&nbsp;in elderly and frail patients with advanced gastroesophageal cancer, according to findings to be presented during&nbsp;the 2019 American Society of Clinical Oncology Annual Meeting.

By eating a balanced, low-fat diet and daily portions of vegetables, fruit, and grains, women have a 21% lower risk of dying from breast cancer, according to research to be presented during the upcoming 2019 ASCO Annual Meeting in Chicago.

The FDA has lifted the partial clinical hold placed on the phase III AIM2CERV trial, which is evaluating axalimogene filolisbac (AXAL) for the treatment of patients with high-risk locally advanced cervical cancer, according to Advaxis, the developer of the investigational immunotherapy agent.

The combination of venetoclax (Venclexta) and obinutuzumab (Gazyva) has been approved by the FDA&nbsp;for the frontline treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma, based on findings from the&nbsp;phase III CLL14 trial.

In an interview with&nbsp;<em>Targeted Oncology</em>, Ian W. Flinn, MD, PhD, discussed the findings from the phase III BRIGHT trial for patients with MCL. He also highlighted the impact of BR in this patient population and other combinations under active investigation.

Myung-Ju Ahn, MD, discusses the results from the AURA LM trial and the next steps that need to be taken in order to confirm the efficacy that was seen with the lower dose. In addition, she highlights where research in the treatment landscape of advanced NSCLC is headed.

The FDA has granted AL101 with an orphan drug designation for the treatment of patients with adenoid cystic carcinoma.

The combination of&nbsp;avelumab (Bavencio) and axitinib (Inlyta) has been approved by the FDA&nbsp;for the frontline treatment of patients with advanced renal cell carcinoma, based on findings from the phase III JAVELIN Renal 101 trial.

In an 8-3 vote, the FDA&rsquo;s Oncologic Drugs Advisory Committee has recommended against approving a new drug application for quizartinib for adult patients with relapsed/refractory&nbsp;FLT3-ITD&ndash;positive acute myeloid leukemia. The FDA is now scheduled to make a final decision on the application by&nbsp;August 25, 2019.

Novel radiotherapeutic CLR 131 has been granted a fast track designation from the FDA as a fourth-line or later treatment for patients with relapsed or refractory multiple myeloma.