Potential Role of Magrolimab in the Treatment of Higher-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

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Hetty Carraway, MD, and Eytan M. Stein, MD, discuss treatment options for patients with higher-risk myelodysplastic syndrome and acute myeloid leukemia, and how to select the best treatment regimen based on patient and disease factors.

EP. 1: An Overview of Myelodysplastic Syndrome (MDS)

Hetty E. Carraway, MD;Eytan M. Stein, MD

September 29th 2022

Eytan M. Stein, MD, provides an overview of myelodysplastic syndrome, including risk factors, symptoms, and diagnosis.

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EP. 2: The Progression of Myelodysplastic Syndrome to Acute Myeloid Leukemia (AML)

Hetty E. Carraway, MD;Eytan M. Stein, MD

September 29th 2022

Hetty Carraway, MD, describes how MDS differs from acute myeloid leukemia (AML), and the percentage of patients who progress to AML from MDS.

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EP. 3: Risk Stratification for Patients with Myelodysplastic Syndrome

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 6th 2022

Dr Eytan M Stein breaks down how patients with MDS are risk-stratified, and how the clinical outcomes differ between risk groups.

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EP. 4: Treatment Goals for Patients with Myelodysplastic Syndrome

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 6th 2022

Experts explain the treatment goals for patients with MDS, and discusses the role of molecular testing in patients with MDS.

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EP. 5: Currently Available Treatment Options for Patients with Higher-Risk Myelodysplastic Syndrome

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 17th 2022

Dr Hetty Carraway reviews the available treatment options for patients with higher-risk MDS, and the biggest challenges of treatment.

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EP. 6: Factors for Consideration when Choosing an Appropriate Treatment for Higher-Risk Myelodysplastic Syndrome

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 17th 2022

Eytan M. Stein, MD, outlines the biggest factors to consider when choosing a treatment for higher-risk MDS, including the differences in quality-of-life for patients.

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EP. 7: The Role of Allogeneic Stem Cell Transplant in Myelodysplastic Syndrome

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 20th 2022

Hetty Carraway, MD, illustrates the role of allogenic stem cell transplant in MDS and the criteria used to determine a patient’s eligibility.

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EP. 8: The Role of Hypomethylating Agents (HMAs) in Higher-Risk Myelodysplastic Syndrome Treatment

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 20th 2022

Key opinion leaders describe the role of hypomethylating agents in treating higher-risk MDS and the treatment options after HMA failure.

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EP. 9: Magrolimab plus Azacitidine for Myelodysplastic Syndrome

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 27th 2022

Drs Stein and Carraway explain the rationale for a magrolimab and azacitidine combination treatment for patients with higher-risk MDS with supporting data from 2 clinical trials.

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EP. 10: Potential Shift in the Treatment Paradigm of Higher-Risk MDS with Magrolimab

Hetty E. Carraway, MD;Eytan M. Stein, MD

October 27th 2022

Dr Hetty Carraway muses on whether magrolimab plus azacitadine will be used as a standard treatment for higher-risk MDS in the future.

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EP. 11: Treating Patients with Myelodysplastic Syndrome and IDH or TP53 Mutations

Hetty E. Carraway, MD;Eytan M. Stein, MD

November 4th 2022

Eytan M. Stein, MD, discusses how to treat patients with MDS who have IDH or TP53 mutations, and whether there is a role for targeted therapy in this patient population.

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EP. 12: Unmet Needs for Patients with Higher-Risk Myelodysplastic Syndrome

Hetty E. Carraway, MD;Eytan M. Stein, MD

November 4th 2022

Dr Carraway highlights some of the most urgent unmet needs for patients with higher-risk MDS.

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EP. 13: ENHANCE-2 Trial of Magrolimab plus Azacitidine in AML

Hetty E. Carraway, MD;Eytan M. Stein, MD

November 10th 2022

Dr Stein explains clinical trial data on the use of magrolimab plus azacitidine for patients with TP53-mutated AML.

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EP. 14: ENHANCE-3 Trial of Magrolimab in Combination with Venetoclax and Azacitidine in AML