Thomas Marron, MD, discusses the rationale for investigating immunotherapy discontinuation in patients with melanoma.
Thomas Marron, MD, an assistant professor of medicine, hematology and medical oncology at Mount Sinai Hospital, discusses the rationale for investigating immunotherapy discontinuation in patients with melanoma.
Marron and colleagues designed a clinical trial to address the challenge of when to stop immunotherapy. This is a hurdle in melanoma, as well as other histologies, because immunotherapies are very effective and more patients are achieving either durable remissions or disease stability. However, patients often remain on these treatments indefinitely.
In the case of nivolumab (Opdivo), the immunotherapeutic agent is given indefinitely, while pembrolizumab (Keytruda) is given for 2 years to patients with melanoma. Although these agents are inching researchers closer towards potentially curing the disease, it is unknown how much of the agent should be used or if physicians can be giving significantly less.
Brain Cancer Awareness Month: Challenges and Innovations in Treatment
May 13th 2024In an interview with Targeted Oncology for Brain Cancer Awareness Month, Theodore Schwartz, MD, discussed the challenges of targeting brain tumors, emerging therapies, and strategies to overcome the blood-brain barrier.
Read More