Naveen Pemmaraju, MD, discusses the next steps for research in the field of myelofibrosis.
Naveen Pemmaraju, MD, associate professor, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, discusses the next steps for research in the field of myelofibrosis.
During the 2020 American Society of Hematology (ASH) Annual Meeting, Pemmaraju presented findings from an add-back strategy with ruxolitinib (Jakafi) plus navitoclax that looked promising for the field, but with the development of novel treatment strategies, he says it is important to look for toxicity, particularly with a new treatment like navitoclax. There is always the risk of thrombocytopenia with JAK inhibitors, so it is important to monitor for both these older and newer toxicities.
The second direction for research is determining how to measure success in the post-frtonline setting. Typically, research looks at spleen and symptom improvement, but in the second-line and beyond, other factors may need to be considered, such as progression-free, event-free, and overall survival. Pemmaraju says some of these patients have a more acute course that can be measured in years while others can have a more chronic disease that is measured in decades.
The third factor for the future of myelofibrosis is understanding the disease itself, and Pemmaraju notes the search for novel biomarkers is also an important area for future research in this field as it can provide physicians more clues as to what patients will benefit from treatment.
Darolutamide Becomes Routine Doublet and Triplet Option in Hormone-Sensitive Prostate Cancer
May 6th 2024Darolutamide has been adopted routinely in clinical practice as a component of both doublet and triplet regimens for the treatment of patients with metastatic hormone-sensitive prostate cancer.
Read More
Responders to UGN-101 Have Positive RFS in Upper Tract Urothelial Cancer
May 5th 2024In patients at 15 centers who had upper tract urothelial cancer, those with no evidence of disease after UGN-101 induction had a 68% rate of 3-year recurrence-free survival, and this outcome did not differ based on tumor status, method of instillation, or treatment intent.
Read More